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Adv Drug Deliv Rev. 2012 May 1;64(6):523-30. doi: 10.1016/j.addr.2011.07.003. Epub 2011 Jul 30.

Gut-associated lymphoid tissues for the development of oral vaccines.

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Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Japan.


Oral vaccine has been considered to be a prospective vaccine against many pathogens especially invading across gastrointestinal tracts. One key element of oral vaccine is targeting efficient delivery of antigen to gut-associated lymphoid tissue (GALT), the inductive site in the intestine where antigen-specific immune responses are initiated. Various chemical and biological antigen delivery systems have been developed and some are in clinical trials. In this review, we describe the immunological features of GALT and the current status of antigen delivery system candidates for successful oral vaccine.

[Indexed for MEDLINE]

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