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Nat Neurosci. 2011 Aug 7;14(9):1109-11. doi: 10.1038/nn.2895.

Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.

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1
Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA.

Abstract

Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

PMID:
21822269
PMCID:
PMC3164920
DOI:
10.1038/nn.2895
[Indexed for MEDLINE]
Free PMC Article

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