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Semin Cell Dev Biol. 2011 Sep;22(7):729-34. doi: 10.1016/j.semcdb.2011.07.021. Epub 2011 Jul 28.

Origins and activity of the Mediator complex.

Author information

1
Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110, USA. rcc@stowers.org

Abstract

The Mediator is a large, multisubunit RNA polymerase II transcriptional regulator that was first identified in Saccharomyces cerevisiae as a factor required for responsiveness of Pol II and the general initiation factors to DNA binding transactivators. Since its discovery in yeast, Mediator has been shown to be an integral and highly evolutionarily conserved component of the Pol II transcriptional machinery with critical roles in multiple stages of transcription, from regulation of assembly of the Pol II initiation complex to regulation of Pol II elongation. Here we provide a brief overview of the evolutionary origins of Mediator, its subunit composition, and its remarkably diverse collection of activities in Pol II transcription.

PMID:
21821140
PMCID:
PMC3207015
DOI:
10.1016/j.semcdb.2011.07.021
[Indexed for MEDLINE]
Free PMC Article

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