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C R Biol. 2011 Aug-Sep;334(8-9):655-61. doi: 10.1016/j.crvi.2011.05.014. Epub 2011 Jul 2.

The evolution of gene expression regulatory networks in yeasts.

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Inserm UMR-S 665, Dynamique des Structures et Interactions des Macromolécules Biologiques, Université Paris Diderot, Sorbonne Paris Cité, INTS, 6 rue Alexandre-Cabanel, 75015 Paris, France.


Gene regulation is a major source of phenotypic diversity between and within species. This aspect of evolution has long been addressed from the sole point of view of the genome sequence. The incredible development of transcriptomics approaches now allows one to actually study the topology and the properties of regulatory networks on an evolutionary perspective. This new discipline is called comparative functional genomics or comparative transcriptomics. This article reviews some of the main advances made in this field, using yeast species, and especially the species sequenced in the frame of the Genolevures program, as a model.

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