Send to

Choose Destination
See comment in PubMed Commons below
Exp Clin Transplant. 2011 Aug;9(4):270-2.

Flupirtine-induced hepatic failure requiring orthotopic liver transplant.

Author information

  • 1Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Charite Campus Mitte, Universitatsmedizin Berlin, Germany.


We present the case of a 48-year-old otherwise healthy man who required an urgent liver transplant owing to acute liver failure after flupirtine treatment. After 3 months of daily flupirtine intake as treatment for pseudoradicular pain syndrome, he presented at our institution with signs of jaundice and hepatic encephalopathy. Laboratory results showed elevated liver transaminases, and the liver histopathology supported the assumed drug-induced liver injury. After listing him for an urgent liver transplant, he was given a liver graft from a 21-year-old man. Despite a rejection episode on day 11 after the surgery (which was successfully treated by steroid pulse therapy), the postoperative course was uneventful and the patient recovered completely. To the best of our knowledge, this is the first report of a liver transplant for acute liver failure after taking flupirtine.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baskent University, Publishers
    Loading ...
    Support Center