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J Am Chem Soc. 2011 Sep 14;133(36):14196-9. doi: 10.1021/ja2054034. Epub 2011 Aug 22.

Expanding the genetic code of an animal.

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1
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK.

Abstract

Genetic code expansion, for the site-specific incorporation of unnatural amino acids into proteins, is currently limited to cultured cells and unicellular organisms. Here we expand the genetic code of a multicellular animal, the nematode Caenorhabditis elegans.

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PMID:
21819153
PMCID:
PMC3168933
DOI:
10.1021/ja2054034
[Indexed for MEDLINE]
Free PMC Article

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