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Cell Mol Life Sci. 2011 Oct;68(19):3175-99. doi: 10.1007/s00018-011-0783-6. Epub 2011 Aug 5.

Advances in tenascin-C biology.

Author information

1
Kennedy Institute of Rheumatology Division, Faculty of Medicine, NDORMS, Oxford University, 65 Aspenlea Road, Hammersmith, London W6 8LH, UK. kim.midwood@kennedy.ox.ac.uk

Abstract

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology.

PMID:
21818551
PMCID:
PMC3173650
DOI:
10.1007/s00018-011-0783-6
[Indexed for MEDLINE]
Free PMC Article
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