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PLoS One. 2011;6(7):e22770. doi: 10.1371/journal.pone.0022770. Epub 2011 Jul 27.

Th17 cells and IL-17 in protective immunity to vaginal candidiasis.

Author information

1
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy.

Abstract

BACKGROUND:

Th17 cells play a major role in coordinating the host defence in oropharyngeal candidiasis. In this study we investigated the involvement of the Th17 response in an animal model of vulvovaginal candidiasis (VVC).

METHODS:

To monitor the course of infection we exploited a new in vivo imaging technique.

RESULTS:

i) The progression of VVC leads to a strong influx of neutrophils in the vagina soon after the challenge which persisted despite the resolution of infection; ii) IL-17, produced by vaginal cells, particularly CD4 T cells, was detected in the vaginal wash during the infection, reaching a maximum 14 days after the challenge; iii) The amount and kinetics of IL-23 in vaginal fluids were comparable to those in vaginal cells; iv) The inhibition of Th17 differentiation led to significant inhibition of IL-17 production with consequent exacerbation of infection; v) An increased production of βdefensin 2 was manifested in cells of infected mice. This production was strongly reduced when Th17 differentiation was inhibited and was increased by rIL-17 treatment.

CONCLUSIONS:

These results imply that IL-17 and Th17, along with innate antimicrobial factors, have a role in the immune response to vaginal candidiasis.

PMID:
21818387
PMCID:
PMC3144947
DOI:
10.1371/journal.pone.0022770
[Indexed for MEDLINE]
Free PMC Article

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