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Leukemia. 2011 Dec;25(12):1797-807. doi: 10.1038/leu.2011.169. Epub 2011 Aug 5.

Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.

Author information

1
Department of Neuropathology, University Hospital of Cologne, Cologne, Germany. martina.deckert@uni-koeln.de

Abstract

Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.

PMID:
21818113
DOI:
10.1038/leu.2011.169
[Indexed for MEDLINE]

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