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Eur J Med Chem. 2011 Sep;46(9):4430-40. doi: 10.1016/j.ejmech.2011.07.015. Epub 2011 Jul 19.

Photodynamic efficacy of water-soluble Si(IV) and Ge(IV) phthalocyanines towards Candida albicans planktonic and biofilm cultures.

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Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad G Bonchev str, Bl 9, 1113 Sofia, Bulgaria.


Water-soluble phthalocyanine complexes of silicon (SiPc1) and germanium (GePc1) were synthesized. The absorbance of SiPc1 in water was with minor aggregation while GePc1 strongly aggregated in water. The fluorescence data in water showed low quantum yields of 0.073 (SiPc1) and 0.01 (GePc1) and similar lifetimes of 4.07 ns and 4.27 ns. The uptake of SiPc1 into Candida albicans cells was two orders of magnitude lower as compared to GePc1 and for both was dependent on the cell density. Fungal cells in suspension were completely inactivated after SiPc1 (1.8 μM) at soft light radiation (50 J cm(-2), 60 mW cm(-2)). The fungal biofilm formed on denture acrylic resin was inactivated with 3 log after fractionated light irradiation.

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