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Behav Brain Res. 2011 Nov 20;225(1):382-7. doi: 10.1016/j.bbr.2011.07.033. Epub 2011 Jul 26.

Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia.

Author information

1
Psychology Department, University of Otago, P.O. Box 56, Dunedin, New Zealand.

Abstract

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.

PMID:
21816179
DOI:
10.1016/j.bbr.2011.07.033
[Indexed for MEDLINE]

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