Send to

Choose Destination
See comment in PubMed Commons below
Qual Life Res. 2012 May;21(4):637-50. doi: 10.1007/s11136-011-9976-6. Epub 2011 Aug 5.

Latent variable mixture models: a promising approach for the validation of patient reported outcomes.

Author information

School of Nursing, Trinity Western University, 7600 Glover Rd, Langley, BC, Canada.



A fundamental assumption of patient-reported outcomes (PRO) measurement is that all individuals interpret questions about their health status in a consistent manner, such that a measurement model can be constructed that is equivalently applicable to all people in the target population. The related assumption of sample homogeneity has been assessed in various ways, including the many approaches to differential item functioning analysis.


This expository paper describes the use of latent variable mixture modeling (LVMM), in conjunction with item response theory (IRT), to examine: (a) whether a sample is homogeneous with respect to a unidimensional measurement model, (b) implications of sample heterogeneity with respect to model-predicted scores (theta), and (c) sources of sample heterogeneity. An example is provided using the 10 items of the Short-Form Health Status (SF-36(®)) physical functioning subscale with data from the Canadian Community Health Survey (2003) (N = 7,030 adults in Manitoba).


The sample was not homogeneous with respect to a unidimensional measurement structure. Specification of three latent classes, to account for sample heterogeneity, resulted in significantly improved model fit. The latent classes were partially explained by demographic and health-related variables.


The illustrative analyses demonstrate the value of LVMM in revealing the potential implications of sample heterogeneity in the measurement of PROs.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center