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Nucleic Acids Res. 2011 Nov;39(21):9061-71. doi: 10.1093/nar/gkr613. Epub 2011 Aug 3.

Handpicking epigenetic marks with PHD fingers.

Author information

1
Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Tatiana.Kutateladze@ucdenver.edu

Abstract

Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic effectors capable of recognizing or 'reading' post-translational histone modifications and unmodified histone tails. These interactions are highly specific and can be modulated by the neighboring epigenetic marks and adjacent effectors. A few PHD fingers have recently been found to also associate with non-histone proteins. In this review, we detail the molecular mechanisms and biological outcomes of the histone and non-histone targeting by PHD fingers. We discuss the significance of crosstalk between the histone modifications and consequences of combinatorial readout for selective recruitment of the PHD finger-containing components of chromatin remodeling and transcriptional complexes.

PMID:
21813457
PMCID:
PMC3241642
DOI:
10.1093/nar/gkr613
[Indexed for MEDLINE]
Free PMC Article

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