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Mol Pharm. 2011 Oct 3;8(5):1985-91. doi: 10.1021/mp200154k. Epub 2011 Aug 10.

Hybrid nanocrystals: achieving concurrent therapeutic and bioimaging functionalities toward solid tumors.

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1
Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, United States.

Abstract

Bioimaging and therapeutic agents accumulated in ectopic tumors following intravenous administration of hybrid nanocrystals to tumor-bearing mice. Solid, nanosized paclitaxel crystals physically incorporated fluorescent molecules throughout the crystal lattice and retained fluorescent properties in the solid state. Hybrid nanocrystals were significantly localized in solid tumors and remained in the tumor for several days. An anticancer effect is expected of these hybrid nanocrystals.

PMID:
21812439
DOI:
10.1021/mp200154k
[Indexed for MEDLINE]
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