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Mol Microbiol. 1990 Jan;4(1):143-50.

Lipid involvement in protein translocation in Escherichia coli.

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1
Centre for Biomembranes and Lipid Enzymology, University of Utrecht, The Netherlands.

Abstract

Signal peptides play an essential role in protein translocation. This review summarizes the current knowledge of the structure of signal peptides and signal peptide-lipid interactions and addresses the possibility that signal peptide-lipid interactions initiate membrane translocation of precursor proteins. A new model for protein translocation in Escherichia coli is proposed, which includes as central features conformational changes of the signal peptide and signal-peptide-induced local changes in membrane organization (non-bilayer lipids).

[Indexed for MEDLINE]

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