Format

Send to

Choose Destination
Arch Pharm Res. 2011 Jul;34(7):1201-8. doi: 10.1007/s12272-011-0719-6. Epub 2011 Aug 3.

The antidiabetic effect of ginsenoside Rb2 via activation of AMPK.

Author information

1
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.

Abstract

Ginsenosides, which are active compounds found in ginseng (Panax ginseng), are used as antidiabetic treatments. The aim of this study was to determine whether Rb2, a type of ginsenoside, regulates hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) and the orphan nuclear receptor small heterodimer partner (SHP) in hyperlipidemic conditions used as an in vitro model of type 2 diabetes. Considering these results, we concluded that Rb2 may inhibit palmitate-induced gluconeogenesis via AMPK-induced SHP by relieving ER stress, a cause of gluconeogenesis.

PMID:
21811928
DOI:
10.1007/s12272-011-0719-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center