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New Microbiol. 2011 Jul;34(3):255-62. Epub 2011 Jul 30.

Synergy of molecular and serological methods in minimally invasive diagnosis of enteroviral cardiac infection.

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Department of Microbiological and Gynecological Sciences, O.U. Clinical Virology, A.O.U. Policlinico-Vittorio Emanuele, P.O. Gaspare Rodolico, Catania, Italy.


Treatment of myocarditis and pericarditis can differ on the basis of aetiology: systemic or auto-immune disease can be positively influenced by corticoid therapy, whereas this kind of treatment can worsen the course of virus-induced disease. Therefore, the aetiological diagnosis is extremely important. The synergistic use of minimally invasive serological, IgG, IgM, IgA, and neutralizing titres, and RNA detection was evaluated on representative patients out of 238 suffering from cardiopathies. The results obtained for each case can yield reliable guidelines that rapidly highlight the presence of a viral aetiology so that an endomyocardial biopsy can be performed thus eliminating incorrect therapies. Thus, not only is this technique rapid, minimally invasive providing the clinician with decisive data, but it is cost effective for the health system.

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