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Br J Haematol. 2011 Oct;155(1):102-5. doi: 10.1111/j.1365-2141.2011.08808.x. Epub 2011 Aug 2.

Pulmonary function in thalassaemia major and its correlation with body iron stores.

Author information

1
Divisions of Pediatric Pulmonology Pediatric Cardiology Hematology, Children's Hospital Los Angeles, 4650 Sunset Blvd, Los Angeles, CA 90027, USA.

Abstract

This study compared pulmonary function tests (PFTs) with cardiac, pancreatic and liver iron in 76 thalassemia major (TM) patients. Restrictive lung disease was observed in 16%, hyperinflation in 32% and abnormal diffusing capacity in 3%. While no patients met Global Initiative for Chronic Lung Disease criteria for airways obstruction, there were indicators of small airways disease and air trapping. PFTs did not correlate with somatic iron burden, blood counts or haemolysis. Restrictive lung disease was associated with inflammation. We conclude that TM patients have pulmonary abnormalities consistent with small airways obstruction. Restrictive disease and impaired diffusion are less common.

PMID:
21810090
PMCID:
PMC3169737
DOI:
10.1111/j.1365-2141.2011.08808.x
[Indexed for MEDLINE]
Free PMC Article

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