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Clinics (Sao Paulo). 2011;66(6):943-7.

Anaphylaxis in Latin America: a report of the online Latin American survey on anaphylaxis (OLASA).

Collaborators (130)

Alassia ML, Arab D, Azua E, Bandin G, Bercoff M, Bessone ME, Borthaburu PH, Bozzola CM, Bracaccini AM, Camps RM, Cardinali SP, Carignano C, Chorzepa G, Colombaro D, Cuello M, De Falco A, De Gennaro MS, Doglia JA, Fasano P, Lujan Ferreyra JC, Festa R, Gambarte FL, Garnero P, Gée MC, Ghiani H, Giovino N, Gomez M, Herrero TV, Imwinkelried Mdel C, Jares E, Kahanovsky NS, Kriunis I, Lisis de Wilson SN, Lucini C, Maldonado AM, Marcipar A, Mindel E, Moisés H, Moura J, Muñoz E, Orellana JC, Jorge Pozo R, Ramon GD, Sacerdote D, Sanabria MS, Sanchez de la Veja W, Sasia L, Sayago L, Seigelshifer D, Serrano RG, Strass MD, Vazquez OT, Yáñez A, Lopez A, Mendonza A, Sea M, Alves M, Britto L, Neto HJ, DiGesu R, Ensina LF, Fernandes F, Geller M, Guedes H, Kuschnir F, Machado M, Miyake A, Naspitz CK, Olivier CE, Santos H, Santos LJ, Tim M, Tava VG, Agar Muñoz AM, Canala-Echevarria R, Espinola E, Guzman MA, Marinovic MA, Parada V, Perez T, Ripoll E, Toche P, Bissinger I, De Zubiria E, Raad RJ, Morena MV, Serrano C, Alvarez M, Rojas OB, Castro RL, Garcia R, Rodriguez O, Ojeda IC, Acuña Gonzalez JL, Palacios R, Tinoco I, Valdivieso R, Viteri ME, Wilches P, Zambrano JH, Venegas Zapata EV, Murillo RC, Enriquez Salazar JR, Gomez M, González-González A, Hernandez LE, Huerta RE, Morfin B, Mortera G, Peña Rued AE, Rodriguez N, Ruiz Dias HM, Segura NH, Solorio H, Soria JE, Vegas AM, Velarde T, Palacios GU, Almillategui D, Guggiari Doutreleau JA, Ratti M, Sisa HR, Farfan R, Gaspar A, Gomes E, Rodrigues-Alves R, Castro G, Morena G, Schuhl JF, Khair FA.

Author information

Division of Allergy, Clinical Immunology and Rheumatology Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.



The aims of the Online Latin American Survey of Anaphylaxis (OLASA) were to identify the main clinical manifestations, triggers, and treatments of severe allergic reactions in patients who were seen by allergists from July 2008 to June 2010 in 15 Latin American countries and Portugal (n =634).


Of all patients, 68.5% were older than 18 years, 41.6% were male, and 65.4% experienced the allergic reaction at home. The etiologic agent was identified in 87.4% of cases and predominantly consisted of drugs (31.2%), foods (23.3%), and insect stings (14.9%). The main symptom categories observed during the acute episodes were cutaneous (94.0%) and respiratory (79.0%). The majority of patients (71.6%) were treated initially by a physician (office/emergency room) within the first hour after the reaction occurred (60.2%), and 43.5% recovered in the first hour after treatment. Most patients were treated in an emergency setting, but only 37.3% received parenteral epinephrine alone or associated with other medication. However, 80.5% and 70.2% were treated with corticosteroids or antihistamines (alone or in association), respectively. A total of 12.9% of the patients underwent reanimation maneuvers, and 15.2% were hospitalized. Only 5.8% of the patients returned to the emergency room after discharge, with 21.7% returning in the first 6 hours after initial treatment.


The main clinical manifestations of severe allergic reactions were cutaneous. The etiologic agents that were identified as causing these acute episodes differed according to age group. Following in order: drugs (31.2%), foods (23.3% and insect stings (14.9%) in adults with foods predominance in children. Treatment provided for acute anaphylactic reactions was not appropriate. It is necessary to improve educational programs in order to enhance the knowledge on this potentially fatal emergency.

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