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Pharmacognosy Res. 2010 Jan;2(1):4-9. doi: 10.4103/0974-8490.60577.

Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicity.

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1
Department of Biomolecular and Physical Sciences, Nathan Campus, Griffith University, 170 Kessels Rd., Nathan, Brisbane, Queensland 4111, Australia.

Abstract

Methanol extracts from S. jambos leaves were tested for antimicrobial activity and toxicity. S. jambos leaf extract inhibited the growth of 4 of the 14 bacteria tested (29%). Both gram-positive and gram-negative bacterial growths were inhibited by S. jambos leaf extract, although gram-positive bacteria appeared more susceptible. Two of the 10 gram-negative bacteria (20%) and 2 of the 4 gram-positive bacteria (50%) tested had their growths inhibited by the extract. The leaf extract also proved to be toxic in the Artemia franciscana bioassay, with a 48-h LC(50) of 387.9 ± 38.8 µg/mL, making it slightly more toxic than Mevinphos (505.3± 37.7 µg/mL) and approximately 5-fold less toxic than potassium dichromate (80.4 ± 4.3 µg/mL). Whilst potassium dichromate's LC(50) remained constant across the 72-hour test period (24-h LC(50), 86.3 ± 5.1; 72-h LC(50), 77.9 ± 4.9), the extract and Mevinphos LC(50) values decreased by 72 hours (87.0 ± 11.3 µg/mL and 103.9 ± 12.8 µg/mL, respectively), indicating their similar levels of toxicity in the assay.

KEYWORDS:

Antibacterial; Syzygium jambos; medicinal plants; methanolic extracts; phytotoxicity; rose apple

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