Format

Send to

Choose Destination
Nat Cell Biol. 2011 Aug 1;13(8):886-8. doi: 10.1038/ncb2311.

esBAF safeguards Stat3 binding to maintain pluripotency.

Abstract

How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3).

PMID:
21808242
DOI:
10.1038/ncb2311
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center