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Curr Opin Struct Biol. 2011 Aug;21(4):517-22. doi: 10.1016/j.sbi.2011.07.001. Epub 2011 Jul 30.

High throughput platforms for structural genomics of integral membrane proteins.

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1
Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA.

Abstract

Structural genomics approaches on integral membrane proteins have been postulated for over a decade, yet specific efforts are lagging years behind their soluble counterparts. Indeed, high throughput methodologies for production and characterization of prokaryotic integral membrane proteins are only now emerging, while large-scale efforts for eukaryotic ones are still in their infancy. Presented here is a review of recent literature on actively ongoing structural genomics of membrane protein initiatives, with a focus on those aimed at implementing interesting techniques aimed at increasing our rate of success for this class of macromolecules.

PMID:
21807498
PMCID:
PMC3172710
DOI:
10.1016/j.sbi.2011.07.001
[Indexed for MEDLINE]
Free PMC Article
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