Format

Send to

Choose Destination
Exp Cell Res. 1990 Apr;187(2):250-4.

The effects of bFGF, IGF-I, and TGF-beta on RMo skeletal muscle cell proliferation and differentiation.

Author information

1
Department of Animal Sciences, University of Arizona, Tucson 85721.

Abstract

A new skeletal muscle cell line, rat myoblast omega or RMo, has been characterized with regard to the effects of three growth factors: basic fibroblast growth factor (bFGF), insulin-like growth factor I (IGF-I), and transforming growth factor beta (TGF-beta). Results indicate a differential response of these factors on both cell proliferation and differentiation. Exposure to bFGF and IGF-I stimulate proliferation, while TGF-beta has no effect on cell number. RMo cell differentiation, as indicated by skeletal myosin synthesis, is enhanced by IGF-I, whereas both bFGF and TGF-beta suppress differentiation. These responses are in agreement with the effects of bFGF, IGF-I, and TGF-beta on myogenic cells cultured from fetal and postnatal muscle, thereby suggesting that RMo cells can serve as a model system for the study of growth factor effects on skeletal muscle cells.

PMID:
2180733
DOI:
10.1016/0014-4827(90)90088-r
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center