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Mayo Clin Proc. 2011 Aug;86(8):805-17. doi: 10.4065/mcp.2011.0247.

Current concepts in antifungal pharmacology.

Author information

1
University of Houston College of Pharmacy and The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA. rlewis@uh.edu

Abstract

The introduction of new antifungal agents (eg, echinocandins, second-generation triazoles) in the past decade has transformed the management of invasive mycoses to the point that drug toxicity is no longer the major limiting factor in treatment. Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for pharmacokinetic drug-drug interactions and unusual toxicities associated with long-term use. This article reviews key pharmacological aspects of systemic antifungal agents as well as evolving strategies, such as pharmacokinetic-pharmacodynamic optimization and therapeutic drug monitoring, to improve the safety and efficacy of systemic antifungal therapy.

PMID:
21803962
PMCID:
PMC3146381
DOI:
10.4065/mcp.2011.0247
[Indexed for MEDLINE]
Free PMC Article

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