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Cell Metab. 2011 Aug 3;14(2):143-4. doi: 10.1016/j.cmet.2011.07.003.

Anaerobicizing into pluripotency.

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1
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Reprogramming involves multiple layers of molecular regulation, yet it remains relatively unknown how the cell's metabolism is changing and/or contributing to this process. In this issue of Cell Metabolism, Folmes et al. (2011) demonstrate that reprogramming induces a bioenergetic transition from an oxidative to a glycolytic state, and provide evidence to suggest that these changes may precede pluripotency.

PMID:
21803281
DOI:
10.1016/j.cmet.2011.07.003
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