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Diabetes Res Clin Pract. 2011 Oct;94(1):126-32. doi: 10.1016/j.diabres.2011.07.004. Epub 2011 Jul 30.

Ten-year incidence of diabetic retinopathy and macular edema. Risk factors in a sample of people with type 1 diabetes.

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1
Ophthalmic Service, Hospital Universitario Sant Joan, IISPV, Universidad Rovira I Virgili, Reus, Tarragona, Spain. promero@grupsagessa.com

Abstract

AIMS:

To determine the 10-year incidence of diabetic retinopathy (DR) and macular edema (DME), and its relationship with its risk factors in a sample of type 1 diabetes mellitus.

METHODS:

A total of 334 patients without diabetic retinopathy at baseline underwent a 10-year prospective study, the risk factors included: age, gender, diabetes duration, HbA1c, LDL-C, HDl-C, TC/HDL-C ratio, ApoA1, ApoB, ApoB/ApoA1 ratio, and triglycerides were recorded. Risk factors for diabetic macular edema (DME) were also recorded.

RESULTS:

The 10-year incidence of any DR was 35.90%, and 11.07% developed DME. The risk factors for DR and DME were: diabetes duration, high glycosylated level, and arterial hypertension, and overt nephropathy was well correlated with DME. The lipid study demonstrated that ApoB/ApoA1 ratio was significant for any DR [HRR: 0.594 (0.416-0.848), p=0.01], and DME [HRR: 0.601 (0.433-0.894), p=0.009]. The TC/HDL ratio was only significant for DME [HRR: 0.624 (0.440-0.886), p=0.008]; other lipids values were not significant for any groups studied.

CONCLUSIONS:

In the present study, the ApoB/ApoA1 ratio was significant to the 10-year incidence of diabetic retinopathy and to macular edema; and the TC/HDL ratio was significant to a 10-year incidence of macular edema.

PMID:
21802760
DOI:
10.1016/j.diabres.2011.07.004
[Indexed for MEDLINE]
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