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J Clin Virol. 2011 Oct;52(2):142-5. doi: 10.1016/j.jcv.2011.06.017. Epub 2011 Jul 28.

A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult.

Author information

1
Clinical and Molecular Virology Unit, University Hospital and EA-4303 Faculty of Medicine, Reims, France. nleveque@chu-reims.fr

Abstract

BACKGROUND:

Human Herpesvirus 6 (HHV-6) is an important cause of fulminant or acute viral myocarditis in immunocompromised or immunocompetent patients. However the physiopathological mechanisms of HHV-6 related acute myocarditis and the involvement of subsequent HHV-6 reactivation phases in the development of chronic cardiomyopathies remain to be assessed.

OBJECTIVES:

To describe a case of fatal HHV-6 chronic myocarditis in an immunocompetent adult.

STUDY DESIGN:

Case report and detailed histological and viral diagnoses by combination of histology/immunohistochemistry and polymerase chain reaction techniques on cardiac tissues.

RESULTS:

Histopathological analysis of ventricular tissues showed large interstitial and scarring fibrotic areas with a moderate mononuclear cell infiltrate compatible with histological aspect of chronic myocarditis. Detection of both HHV-6 by real-time PCR and viral glycoproteins in mononuclear and endothelial cells by immunohistochemistry evidenced an ongoing cardiac HHV-6 replication with viral late protein synthesis activity.

CONCLUSIONS:

This case report indicates that HHV-6 can establish a chronic active myocarditis leading to heart failure in immunocompetent subjects.

PMID:
21802354
DOI:
10.1016/j.jcv.2011.06.017
[Indexed for MEDLINE]

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