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Chem Biol. 2011 Jul 29;18(7):819-20. doi: 10.1016/j.chembiol.2011.07.002.

Size effect in molecular imaging of vascular endothelial growth factor.

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Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.


Visualizing and quantifying vascular endothelial growth factor (VEGF) levels are crucial factors in understanding the tumor environment and monitoring antiangiogenic treatment. The small peptidic probes described by Fedorova et al. in this issue appear to be superior to antibodies in reflecting the dynamics of VEGF as they facilitate image quantification.

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