Format

Send to

Choose Destination
Emerg Infect Dis. 2011 Aug;17(8):1355-63. doi: 10.3201/eid1708.110114.

Seroprevalence of trichodysplasia spinulosa-associated polyomavirus.

Author information

1
Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. p.z.van_der_meijden@lumc.nl

Abstract

We identified a new polyomavirus in skin lesions from a patient with trichodysplasia spinulosa (TS). Apart from TS being an extremely rare disease, little is known of its epidemiology. On the basis of knowledge regarding other polyomaviruses, we anticipated that infections with trichodysplasia spinulosa-associated polyomavirus (TSV) occur frequently and become symptomatic only in immunocompromised patients. To investigate this hypothesis, we developed and used a Luminex-based TSV viral protein 1 immunoassay, excluded cross-reactivity with phylogenetically related Merkel cell polyomavirus, and measured TSV seroreactivity. Highest reactivity was found in a TS patient. In 528 healthy persons in the Netherlands, a wide range of seroreactivities was measured and resulted in an overall TSV seroprevalence of 70% (range 10% in small children to 80% in adults). In 80 renal transplant patients, seroprevalence was 89%. Infection with the new TSV polyomavirus is common and occurs primarily at a young age.

PMID:
21801610
PMCID:
PMC3381547
DOI:
10.3201/eid1708.110114
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center