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Trends Biochem Sci. 1990 Jan;15(1):6-10.

Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology.

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1
Institut de Pharmacologie Mol├ęculaire et Cellulaire du CNRS, Valbonne, France.

Abstract

The action of fluoride ions on G proteins as well as on various ATPases and phosphatases, is related to their complexation with traces of aluminium or beryllium. These fluorometallic complexes act as analogs of phosphate: they bind with high affinity, but reversibly, in phosphate sites or, concomitantly with nucleoside-diphosphate, in nucleoside-triphosphate sites. The beryllofluoride complexes are strictly tetrahedral; they cannot take on the pentavalent conformation adopted by phosphate in transition states hence they interfere with phospho-transfer reaction mechanisms.

PMID:
2180149
DOI:
10.1016/0968-0004(90)90117-t
[Indexed for MEDLINE]

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