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Trends Biochem Sci. 1990 Jan;15(1):30-3.

Salmonella virulence: new clues to intramacrophage survival.

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Biology Department, University of California, San Diego, La Jolla 92093.


Salmonella are capable of survival in macrophages (cells which have evolved specific mechanisms to kill pathogenic bacteria). One mechanism involves the bactericidal peptides called defensins which insert into phospholipid bilayers to generate transmembrane pores. Synthesis of the Salmonella gene products which determine resistance to defensins has been found to be under the control of a transcriptional regulatory protein termed PhoP.

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