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World J Gastroenterol. 2011 Jul 7;17(25):3054-9. doi: 10.3748/wjg.v17.i25.3054.

Epidemiological and clinical features of hepatitis B virus related liver failure in China.

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1
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Abstract

AIM:

To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.

METHODS:

This study was conducted with a retrospective design to examine 1066 patients with HBV-related liver failure in the southwest of China.

RESULTS:

There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the largest proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had definite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and ≥ 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis.

CONCLUSION:

Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.

KEYWORDS:

Chronic hepatitis B; Epidemiology; Hepatitis B virus related liver failure; Prognosis

PMID:
21799653
PMCID:
PMC3132258
DOI:
10.3748/wjg.v17.i25.3054
[Indexed for MEDLINE]
Free PMC Article
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