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World J Gastroenterol. 2011 Jul 7;17(25):3054-9. doi: 10.3748/wjg.v17.i25.3054.

Epidemiological and clinical features of hepatitis B virus related liver failure in China.

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Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.



To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China.


This study was conducted with a retrospective design to examine 1066 patients with HBV-related liver failure in the southwest of China.


There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the largest proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had definite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and ≥ 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis.


Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.


Chronic hepatitis B; Epidemiology; Hepatitis B virus related liver failure; Prognosis

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