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Neuro Oncol. 2011 Aug;13(8):880-5. doi: 10.1093/neuonc/nor071.

Gene-protein correlation in single cells.

Author information

1
Northwestern Brain Tumor Institute, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Abstract

We present a novel methodology combining traditional fluorescent in situ hybridization with an in situ protein detection technology called proximity ligation assay. This method has potential to perform a detailed analysis of the relationship between gene status and corresponding protein expression in cells and tissues. We demonstrate that the fluorescent in situ gene protein assay methodology is capable of resolving gene and protein patterns simultaneously on a cell-by-cell basis.

PMID:
21798849
PMCID:
PMC3145472
DOI:
10.1093/neuonc/nor071
[Indexed for MEDLINE]
Free PMC Article
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