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Antiviral Res. 2011 Sep;91(3):330-4. doi: 10.1016/j.antiviral.2011.07.011. Epub 2011 Jul 21.

Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro.

Author information

1
Department of Microbiology, The University of Hong Kong, Hong Kong, China. suki@hkucc.hku.hk

Abstract

A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.

PMID:
21798291
DOI:
10.1016/j.antiviral.2011.07.011
[Indexed for MEDLINE]

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