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Chem Phys Lipids. 2011 Oct;164(7):626-35. doi: 10.1016/j.chemphyslip.2011.07.003. Epub 2011 Jul 20.

n-3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization.

Author information

1
Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, College Station, TX 77843-1313, USA. mcmurray@medicine.tamhsc.edu

Abstract

It is now well established that dietary lipids are incorporated into macrophage and T-cell membrane microdomains, altering their structure and function. Within cell membranes, there are specific detergent-resistant domains in which key signal transduction proteins are localized. These regions are classified as "lipid rafts". Rafts are composed mostly of cholesterol and sphingolipids and therefore do not integrate well into the fluid phospholipid bilayers causing them to form microdomains. Upon cell activation, rafts compartmentalize signal-transducing molecules, thus providing an environment conducive to signal transduction. In this review, we discuss recent novel data describing the effects of n-3 PUFA on alterations in the activation and functions of macrophages and T-cells. We believe that the modifications in these two disparate immune cell types are linked by fundamentally similar changes in membrane lipid composition and transmembrane signaling functions. We conclude that the outcomes of n-3 PUFA-mediated immune cell alterations may be beneficial (e.g., anti-inflammatory) or detrimental (e.g., loss of microbial immunity) depending upon the cell type interrogated.

PMID:
21798252
PMCID:
PMC3183364
DOI:
10.1016/j.chemphyslip.2011.07.003
[Indexed for MEDLINE]
Free PMC Article
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