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J Coll Physicians Surg Pak. 2011 Aug;21(8):450-4. doi: 08.2011/JCPSP.450454.

Pregnancy-associated plasma protein-A levels in individuals with and without coronary artery disease.

Author information

1
Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi. dr_najeebkhan@hotmail.com

Abstract

OBJECTIVE:

To compare pregnancy-associated plasma protein-A (PAPP-A) levels in individuals with and without coronary artery disease (CAD).

STUDY DESIGN:

Cross-sectional comparative study.

PLACE AND DURATION OF STUDY:

Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, in collaboration with Armed Forces Institute of Cardiology (AFIC), from September 2008 to March 2010.

METHODOLOGY:

One hundred and twenty five (125) individuals both male and female were included in the study. Blood for PAPP-A and lipid profile was collected, just before angiography. On the basis of angiography, the individuals were divided into those with and without CAD. PAPP-A was analyzed by using Diagnostic System Laboratories (DSL) Enzyme Linked Immunosorbent Assay (ELISA) kit and reading was taken by ELISA reader. Lipid profile was determined on automated analyzers Selectra-2 and Vitros 5.1.

RESULTS:

Amongst the 125 individuals, 41 individuals were without CAD whereas 84 individuals were having CAD. Mean PAPP-A levels were 0.74 ± 0.35 mIU/L in those without CAD whereas mean PAPP-A levels in those with CAD were 1.35 ± 0.57 mIU/L. The difference between the two groups was statistically significant (p < 0.001). A PAPP-A cut off level of 0.85 mIU/L had a sensitivity and specificity of 78% and 70% respectively for diagnosing atherosclerotic CAD.

CONCLUSION:

PAPP-A is a potentially relevant marker of the presence and extent of coronary atherosclerosis as its levels are elevated in CAD as compared to individuals without CAD.

PMID:
21798128
DOI:
08.2011/JCPSP.450454
[Indexed for MEDLINE]

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