Format

Send to

Choose Destination
Kidney Int. 1990 Mar;37(3):965-70.

Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulonephritis.

Author information

1
Office of the Regius Professor of Physic, Clinical Medical School, Addenbrookes Hospital, Cambridge, United Kingdom.

Abstract

The incidence of autoantibodies to glomerular basement membrane (AGBMA) and neutrophil cytoplasmic antigens (ANCA) in the initial sera of 889 consecutive patients with a suspected diagnosis of rapidly progressive glomerulonephritis, was determined by prospective study. Forty-seven (5%) were positive for AGBMA alone, 246 (28%) were positive for ANCA alone, 576 (65%) had neither autoantibodies while 20 (2%) had both. Clinical and pathological data collected from patients with both autoantibodies suggested the coexistence of anti-glomerular basement membrane disease and systemic vasculitis. Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.

PMID:
2179617
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center