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J Immunol. 2011 Sep 1;187(5):2067-71. doi: 10.4049/jimmunol.1100833. Epub 2011 Jul 27.

Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.

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1
Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.

Abstract

The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS1 depletion selectively enhances such chemotaxis in gut T cells and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease.

PMID:
21795595
PMCID:
PMC3166702
DOI:
10.4049/jimmunol.1100833
[Indexed for MEDLINE]
Free PMC Article
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