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Crit Rev Food Sci Nutr. 2011 Aug;51(7):626-34. doi: 10.1080/10408391003748100.

The bioactivity of pomegranate: impact on health and disease.

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Biochemistry Department (U38-FCT), Faculty of Medicine, University of Porto, 4200-319, Porto, Portugal.


The aim of the present review is to discuss the cumulative evidence that suggests that pomegranate consumption possesses a diverse array of biological actions and may be helpful in the prevention of some inflammatory-mediated diseases including cancer. The pomegranate fruit can be divided into at least three parts-seeds, peel, and juice. All these components have been studied for their antioxidant properties in a chemoprevention approach. Pomegranate exerts antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through modulation of Bcl-2 proteins, increases p21 and p27, and downregulates cyclin-cdk network. In addition, pomegranate inhibits the activation of inflammatory pathways including, but not limited to, the NF╬║-B pathway. Anti-cancer effects with the most impressive data have been demonstrated so far in prostate cancer.

[Indexed for MEDLINE]

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