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Endocr Regul. 2011 Jul;45(3):131-7.

7-hydroxylated derivatives of dehydroepiandrosterone as possibly related to menstrual mood change in healthy women.

Author information

1
Institute of Endocrinology, Prague, Czech Republic. mduskova@endo.cz

Abstract

OBJECTIVE:

Mood changes occur often in the luteal phase of menstrual cycle. Steroids modulating GABAA and NAMD receptors in the brain, namely allopregnanolone, were suggested as a factor of premenstrual syndrome. Another neurosteroid influencing the well-being is dehydroepiandrosterone. In the past decade it was shown by several authors that some dehydroepiandrosterone derivatives, especially those with 7-hydroxy- or 7-oxo group, exert a higher activity than dehydroepiandrosterone itself. It was also reasonable to see whether the levels of circulating 7-hydroxy-derivatives of dehydroepiandrosterone differ in the follicular and luteal phase of the menstrual cycle.

METHODS:

Steroids known to exert neuroprotective effects, namely 7α- and 7β-hydroxy-dehydroepiandrosterone, 5-androstene-3β,7α,17β-triol and 5-androstene-3β,7β,17β-triol, were determined in midfollicular and midluteal phase of the menstrual cycle of 22 healthy women with a regular menstruation cycle.

RESULTS:

Whereas the maternal steroids, dehydroepiandrosterone and androstene-3β,17β-diol showed no significant difference between the phases of menstrual cycle, the levels of their 7-hydroxylated metabolites were significantly lower in the luteal phase.

CONCLUSION:

It is suggested that the observed decrease of 7-hydroxylated metabolites during the luteal phase may be a factor related to the etiopathogenesis of mood change and neurocognitive disturbances, which are known to be more accented in that particular phase of the menstrual cycle.

PMID:
21793625
[Indexed for MEDLINE]

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