Send to

Choose Destination
See comment in PubMed Commons below
Med Res Rev. 2012 Jul;32(4):868-905. doi: 10.1002/med.20250. Epub 2011 Jul 26.

Radiohalogenated nonnatural amino acids as PET and SPECT tumor imaging agents.

Author information

  • 1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.


Radiohalogenated α-amino acids are a diverse and useful class tumor imaging agents suitable for positron emission tomography and single photon emission computed tomography. These tracers target the increased rates of amino acid transport exhibited by many tumor cells. The most established clinical use for radiolabeled amino acids is imaging primary and recurrent gliomas, and there is growing evidence that they may also be useful for other oncologic applications, including neuroendocrine tumors and prostate cancer. This review focuses on the synthesis, radiolabeling, and preclinical evaluation of three series of nonnatural radiohalogenated amino acids: alicyclic, α,α-dialkyl, and 1H-[1,2,3]triazole amino acids which target system L, system A, and cationic amino acid transport systems, respectively.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center