Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Immunol. 2011 Aug;41(8):2142-4. doi: 10.1002/eji.201141858.

TLR9 regulation by proteolysis: a friend or a foe.

Author information

1
Institut National de la Santé et la Recherche Médicale, Paris, France. benedicte.manoury@inserm.fr

Abstract

Intracellular TLRs sense viral and bacterial nucleic acids from a wide variety of pathogens. Previous studies have shown that TLR9 requires processing for signalling. Following proteolysis, a fragment corresponding to the C-terminal part of TLR9 was shown to bind MyD88 and to induce signalling when cells were stimulated with TLR9 ligands. In this issue of the European Journal of Immunology, a study provides evidence that another proteolytic fragment of TLR9 is generated, different to that described previously, consisting of amino acids 1-723 which mediates inhibition of TLR9 signalling. These results suggest that proteolysis undoubtedly is a key step in TLR9 regulation.

PMID:
21792872
DOI:
10.1002/eji.201141858
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center