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Br J Cancer. 2011 Aug 23;105(5):602-5. doi: 10.1038/bjc.2011.271. Epub 2011 Jul 26.

Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration.

Author information

1
Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA. sutcliffes@wudosis.wustl.edu

Abstract

BACKGROUND:

We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.

METHODS:

We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.

RESULTS:

Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively).

CONCLUSION:

Chlamydia and gonorrhoea may infect the prostate of some infected men.

PMID:
21792196
PMCID:
PMC3188942
DOI:
10.1038/bjc.2011.271
[Indexed for MEDLINE]
Free PMC Article
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