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J Pediatr Hematol Oncol. 2011 Aug;33(6):e258-60. doi: 10.1097/MPH.0b013e318212ecb3.

Infantile choriocarcinoma in a neonate with massive liver involvement cured with chemotherapy and liver transplant.

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Alfred I. duPont Hospital for Children, Wilmington, DE, USA.


A 6-week-old boy presented with fever, pallor, and hepatomegaly. Ultrasound showed a huge midline abdominal mass. β-human chorionic gonadotropin was markedly elevated, suggesting a diagnosis of infantile choriocarcinoma of the liver. A biopsy confirmed the diagnosis. The patient received 6 cycles of bleomycin, cisplatin, and etoposide with significant decrease in tumor size. However, the tumor remained unresectable. A donor liver became available, and the infant underwent successful liver transplantation. He received 2 posttransplant cycles of moderate dose of methotrexate. This case shows the use of liver transplantation in cases of infantile choriocarcinoma of the liver where the tumor remains unresectable despite chemotherapy.

[Indexed for MEDLINE]

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