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Development. 2011 Aug;138(16):3343-56. doi: 10.1242/dev.058230.

An emerging role for TOR signaling in mammalian tissue and stem cell physiology.

Author information

1
Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093-0815, USA. kuguan@ucsd.edu

Abstract

The mammalian target of rapamycin (mTOR) is a kinase that responds to a myriad of signals, ranging from nutrient availability and energy status, to cellular stressors, oxygen sensors and growth factors. The finely tuned response of mTOR to these stimuli results in alterations to cell metabolism and cell growth. Recent studies of conditional knockouts of mTOR pathway components in mice have affirmed the role of mTOR signaling in energy balance, both at the cell and whole organism levels. Such studies have also highlighted a role for mTOR in stem cell homeostasis and lifespan determination. Here, we discuss the molecular mechanisms of TOR signaling and review recent in vitro and in vivo studies of mTOR tissue-specific activities in mammals.

PMID:
21791526
PMCID:
PMC3143559
DOI:
10.1242/dev.058230
[Indexed for MEDLINE]
Free PMC Article
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