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Neurosci Lett. 2011 Sep 1;501(3):185-7. doi: 10.1016/j.neulet.2011.05.245. Epub 2011 Jul 20.

HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease.

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Center for Experimental Medicine, The Third Xiangya Hospital, Central South University, Changsha, China.


Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (χ²)=6.446, p=0.040 for genotypic distribution; χ²=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population.

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