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J Infect. 2011 Sep;63(3):223-8. doi: 10.1016/j.jinf.2011.07.006. Epub 2011 Jul 20.

Two cases illustrating successful adjunctive interferon-γ immunotherapy in refractory disseminated coccidioidomycosis.

Author information

1
Infectious Disease Naval Hospital, Naval Medical Center San Diego, 34800 Bob Wilson Drive, Ste. 5, San Diego, CA 92134-1005, USA. christopher.duplessis@med.navy.mil

Abstract

Protective immunity and host resistance to coccidioidomycosis require a robust cell-mediated immunity with adequate production of Th1 cytokines including interleukin-12, and IFN-γ and appropriate regulation and coordinated functionality of Th1/Th2 responses and IL-12/IFN-γ cytokine axes. IFN-γ augments the anti-fungal activity of effector immune cells against a variety of fungi. Numerous animal models have demonstrated the potential efficacy of adjunctive IFN-γ in treatment of invasive mycoses. Yet, despite these promising data, a paucity of literature documents efficacious adjunctive IFN-γ administration in refractory coccidioidomycosis. We present two cases of refractory disease occurring at our institution who responded to adjunctive IFN-γ.

PMID:
21791226
PMCID:
PMC4103908
DOI:
10.1016/j.jinf.2011.07.006
[Indexed for MEDLINE]
Free PMC Article

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