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Ther Adv Med Oncol. 2010 Jan;2(1):25-37. doi: 10.1177/1758834009356014.

Targeted therapies in small cell lung cancer: a review.

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Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.


Small cell lung cancer (SCLC) is an aggressive form of lung cancer that is characterized by a rapid doubling time, early onset of dissemination and high sensitivity to chemotherapy. Despite the potential for cure in patients with limited disease with concurrent chemoradiation and an initial good response to chemotherapy in extensive disease, there is a high chance of disease relapse with an overall poor median survival for both stages. With increasing translational research and a better understanding of the molecular basis of cancer, a number of molecular targets have been identified in various preclinical studies. This review summarizes potentially viable targets and new agents that have been developed and employed in recent, ongoing and future clinical trials to attempt to improve clinical outcomes in this disease.


BH3 mimetics; MET inhibitors; angiogenesis inhibitors; apoptosis promoters; cell signalling inhibitors; multidrug resistance inhibitors; small cell lung cancer (SCLC); targeted therapies; vaccines

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