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Neuro Oncol. 2011 Aug;13(8):857-65. doi: 10.1093/neuonc/nor073. Epub 2011 Jul 25.

Cilengitide induces autophagy-mediated cell death in glioma cells.

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1
William and Karen Davidson Laboratory of Cell Signaling and Tumorigenesis, Detroit, MI 48202, USA.

Abstract

We studied the effect of the integrin inhibitor cilengitide in glioma cells. Cilengitide induced cell detachment and decreased cell viability, and induction of autophagy followed by cell apoptosis. In addition, cilengitide decreased the cell renewal of glioma stem-like cells (GSCs). Inhibition of autophagy decreased the cytotoxic effect of cilengitide. Pretreatment of glioma cells and GSCs with cilengitide prior to γ-irradiation resulted in a larger increase in autophagy and a more significant decrease in cell survival. We found that cilengitide induced autophagy collectively in glioma cells, xenografts, and GSCs, which contributed to its cytotoxic effects and sensitized these cells to γ-radiation.

PMID:
21788343
PMCID:
PMC3145473
DOI:
10.1093/neuonc/nor073
[Indexed for MEDLINE]
Free PMC Article
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