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Mitochondrion. 2012 Jan;12(1):66-76. doi: 10.1016/j.mito.2011.07.003. Epub 2011 Jul 20.

Regulation and protection of mitochondrial physiology by sirtuins.

Author information

1
CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.

Abstract

The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD(+)-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies.

PMID:
21787885
DOI:
10.1016/j.mito.2011.07.003
[Indexed for MEDLINE]

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