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Mitochondrion. 2012 Jan;12(1):66-76. doi: 10.1016/j.mito.2011.07.003. Epub 2011 Jul 20.

Regulation and protection of mitochondrial physiology by sirtuins.

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CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.


The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD(+)-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies.

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